Effector Therapeutics

About:

Effector Therapeutics is an early-stage company focused on the discovery and development of small molecule cancer therapeutics.

Website: http://effector.com

Top Investors: Alexandria Venture Investments, AbbVie, Mission BioCapital, U.S. Venture Partners, SR One

Description:

eFFECTOR is a clinical stage biopharmaceutical company focused on pioneering the development of a new class of oncology drugs referred to as selective translation regulator inhibitors (STRIs). eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase 1/2 (MNK 1/2). The eIF4F complex is a central node where two of the most frequently mutated signaling pathways in cancer, the PI3K-AKT and RAS-MEK pathways, converge to activate the translation of select messenger RNA into proteins that are frequent culprits in key disease driving processes. Each of eFFECTOR’s product candidates is designed to act on a single protein that drives the expression of multiple functionally related proteins, including oncoproteins and immunosuppressive proteins in T cells, that together control tumor growth, survival and immune evasion. eFFECTOR’s lead product candidate, tomivosertib, is a MNK 1/2 inhibitor. KICKSTART, a randomized, double-blind, placebo controlled Phase 2b trial of tomivorsertib in NSCLC in combination with pembrolizumab is currently open for enrollment. Zotatifin, eFFECTOR’s inhibitor of eIF4A, is currently in the dose-escalation portion of a Phase 1/2 trial, with Phase 2a expansion cohorts expected to initiate in the second half of 2021. eFFECTOR has a global collaboration with Pfizer to develop inhibitors of a third target, eIF4E.

Total Funding Amount:

$243M

Estimated Revenue Range:

$10M to $50M

Headquarters Location:

San Diego, California, United States

Founded Date:

2012-01-01

Contact Email:

info(AT)effector.com

Founders:

Davide Ruggero, Kevan Shokat, Kevin Eastwood, Siegfried Reich

Number of Employees:

11-50

Last Funding Date:

2024-01-25

IPO Status:

Public

Industries:

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